How much caffeine is in Excedrin Migraine?

One caplet of Excedrin Migraine contains 65 mg of caffeine.

That's about three quarters of a cup of brewed coffee, and 16% of the 400 mg a day the FDA cites for most healthy adults.

Source: excedrin.com · checked 10 Nov 2026

When did you take it?

Taken at 3 pm, about 23 mg is still in you at an 11 pm bedtime. That should not affect most people’s sleep.

Bedtime

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Latest time to take it

For an 11 pm bedtime, one caplet of Excedrin Migraine taken by about 8:45 pm keeps most people under 50 mg of caffeine through the night. The table works it out for other bedtimes and for how sensitive you are: it is the latest time to take one so that the caffeine left stays under the line all night.

Bedtime	Very sensitive under 25 mg	Average under 50 mg	Not very sensitive under 100 mg
9 pm	1:40 pm	6:45 pm	Any time
10 pm	2:40 pm	7:45 pm	Any time
11 pm	3:40 pm	8:45 pm	Any time
Midnight	4:40 pm	9:45 pm	Any time
1 am	5:40 pm	10:45 pm	Any time

One unit as listed on the label, average clearance (half-life 5 h), 8 hours of sleep. "Any time" means even one at bedtime stays under the line. Follow the label or ask your pharmacist about how much and how often to take it; this table is only about sleep.

How long it lasts

The caffeine from one caplet of Excedrin Migraine peaks in your blood about 70 minutes after you take it, at roughly 56 mg. Half of it is gone in about 5 hours for an average adult; that ranges from roughly 3 to 7 hours, and longer in pregnancy or with some medicines.

Time after	3 hours	6 hours	9 hours	12 hours
Still in you	45 mg	30 mg	20 mg	13 mg

So one taken at 3 pm leaves about 23 mg at 11 pm. How long caffeine lasts explains the curve.

How it compares

Excedrin Migraine is stronger than 15% of the 34 supplements and medicines we track, by caffeine per serving.

To reach 400 mg in a day you would need about 6 of these.

Less caffeine

Midol Complete 60 mg, 1 caplet
Butalbital, Acetaminophen and Caffeine (Fioricet) 40 mg, 1 capsule
Bayer Back & Body 33 mg, 1 caplet

More caffeine

Amino Energy 100 mg, 1 serving
Ergotamine and Caffeine (Cafergot) 100 mg, 1 tablet
G FUEL Energy Formula 140 mg, 1 scoop

Same caffeine: BC Powder, Excedrin Extra Strength, Excedrin Tension Headache.

FAQ

Is Excedrin Migraine high in caffeine?

It is moderate. One caplet of Excedrin Migraine contains 65 mg, which is 68% of the 95 mg in an 8 fl oz cup of brewed coffee.

Can I take Excedrin Migraine at night?

Earlier is better. Taken at 7 pm, it leaves about 39 mg in an average adult at an 11 pm bedtime. The latest time for an 11 pm bedtime is about 8:45 pm.

How long does the caffeine in Excedrin Migraine last?

It peaks about 70 minutes after you take it. Of the 65 mg, about 30 mg is still in you 6 hours later and 13 mg after 12 hours, for an average adult with a 5-hour half-life.

Does Excedrin Migraine have more caffeine than a cup of coffee?

No. One caplet of Excedrin Migraine contains 65 mg; an 8 fl oz cup of coffee has 95 mg.

Method and limits

The caffeine figure comes from excedrin.com; it is the amount the label lists per unit. The curves use a standard one-compartment model with an average 5-hour half-life and a sleep-friendly line of 50 mg; your own body may clear caffeine faster or slower. How it works has the details.

These are estimates for information, not medical advice. This is a medicine: follow the label and ask your pharmacist or doctor about dosing.

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