How much caffeine is in ergotamine and caffeine (Cafergot)?

One tablet of ergotamine and caffeine (Cafergot) contains 100 mg of caffeine.

That's about one cup of brewed coffee, and a quarter of the 400 mg a day the FDA cites for most healthy adults.

Source: DailyMed (U.S. National Library of Medicine) · checked 10 Nov 2026

When did you take it?

Taken at 3 pm, about 35 mg is still in you at an 11 pm bedtime. That should not affect most people’s sleep.

Bedtime

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Latest time to take it

For an 11 pm bedtime, one tablet of ergotamine and caffeine (Cafergot) taken by about 5:35 pm keeps most people under 50 mg of caffeine through the night. The table works it out for other bedtimes and for how sensitive you are: it is the latest time to take one so that the caffeine left stays under the line all night.

Bedtime	Very sensitive under 25 mg	Average under 50 mg	Not very sensitive under 100 mg
9 pm	10:35 am	3:35 pm	Any time
10 pm	11:35 am	4:35 pm	Any time
11 pm	12:35 pm	5:35 pm	Any time
Midnight	1:35 pm	6:35 pm	Any time
1 am	2:35 pm	7:35 pm	Any time

One unit as listed on the label, average clearance (half-life 5 h), 8 hours of sleep. "Any time" means even one at bedtime stays under the line. Follow the label or ask your pharmacist about how much and how often to take it; this table is only about sleep.

How long it lasts

The caffeine from one tablet of ergotamine and caffeine (Cafergot) peaks in your blood about 70 minutes after you take it, at roughly 85 mg. Half of it is gone in about 5 hours for an average adult; that ranges from roughly 3 to 7 hours, and longer in pregnancy or with some medicines.

Time after	3 hours	6 hours	9 hours	12 hours
Still in you	69 mg	46 mg	30 mg	20 mg

So one taken at 3 pm leaves about 35 mg at 11 pm. How long caffeine lasts explains the curve.

How it compares

Ergotamine and caffeine (Cafergot) is stronger than 33% of the 34 supplements and medicines we track, by caffeine per serving.

To reach 400 mg in a day you would need about 4 of these.

Less caffeine

BC Powder 65 mg, 1 powder packet
Excedrin Extra Strength 65 mg, 1 caplet
Excedrin Migraine 65 mg, 1 caplet

More caffeine

G FUEL Energy Formula 140 mg, 1 scoop
C4 Ripped 150 mg, 1 scoop
Goody's Hangover Powder 150 mg, 1 powder packet

Same caffeine: Amino Energy.

FAQ

Is ergotamine and caffeine (Cafergot) high in caffeine?

Yes. One tablet of ergotamine and caffeine (Cafergot) contains 100 mg, which is about the same as an 8 fl oz cup of brewed coffee (95 mg).

Can I take ergotamine and caffeine (Cafergot) at night?

Not if you want to sleep well. Taken at 7 pm, it leaves about 60 mg in an average adult at an 11 pm bedtime, above the 50 mg most people sleep fine with. The latest time for an 11 pm bedtime is about 5:35 pm.

How long does the caffeine in ergotamine and caffeine (Cafergot) last?

It peaks about 70 minutes after you take it. Of the 100 mg, about 46 mg is still in you 6 hours later and 20 mg after 12 hours, for an average adult with a 5-hour half-life.

Does ergotamine and caffeine (Cafergot) have more caffeine than a cup of coffee?

Yes. One tablet of ergotamine and caffeine (Cafergot) contains 100 mg; an 8 fl oz cup of coffee has 95 mg.

Method and limits

The caffeine figure comes from DailyMed (U.S. National Library of Medicine); it is the amount the label lists per unit. The curves use a standard one-compartment model with an average 5-hour half-life and a sleep-friendly line of 50 mg; your own body may clear caffeine faster or slower. How it works has the details.

These are estimates for information, not medical advice. This is a medicine: follow the label and ask your pharmacist or doctor about dosing.