How much caffeine is in Midol Complete?

One caplet of Midol Complete contains 60 mg of caffeine.

That's about half a cup of brewed coffee, and 15% of the 400 mg a day the FDA cites for most healthy adults.

Source: DailyMed (U.S. National Library of Medicine) · checked 10 Nov 2026

When did you take it?

Taken at 3 pm, about 21 mg is still in you at an 11 pm bedtime. That should not affect most people’s sleep.

Bedtime

Add this to my day

Your whole day, every drink, in the free CaffeineIQ check. The iPhone app is coming soon.

Latest time to take it

For an 11 pm bedtime, one caplet of Midol Complete taken by about 9:25 pm keeps most people under 50 mg of caffeine through the night. The table works it out for other bedtimes and for how sensitive you are: it is the latest time to take one so that the caffeine left stays under the line all night.

Bedtime	Very sensitive under 25 mg	Average under 50 mg	Not very sensitive under 100 mg
9 pm	2:15 pm	7:25 pm	Any time
10 pm	3:15 pm	8:25 pm	Any time
11 pm	4:15 pm	9:25 pm	Any time
Midnight	5:15 pm	10:25 pm	Any time
1 am	6:15 pm	11:25 pm	Any time

One unit as listed on the label, average clearance (half-life 5 h), 8 hours of sleep. "Any time" means even one at bedtime stays under the line. Follow the label or ask your pharmacist about how much and how often to take it; this table is only about sleep.

How long it lasts

The caffeine from one caplet of Midol Complete peaks in your blood about 70 minutes after you take it, at roughly 51 mg. Half of it is gone in about 5 hours for an average adult; that ranges from roughly 3 to 7 hours, and longer in pregnancy or with some medicines.

Time after	3 hours	6 hours	9 hours	12 hours
Still in you	42 mg	27 mg	18 mg	12 mg

So one taken at 3 pm leaves about 21 mg at 11 pm. How long caffeine lasts explains the curve.

How it compares

Midol Complete is stronger than 12% of the 34 supplements and medicines we track, by caffeine per serving.

To reach 400 mg in a day you would need about 6½ of these.

Less caffeine

Butalbital, Acetaminophen and Caffeine (Fioricet) 40 mg, 1 capsule
Bayer Back & Body 33 mg, 1 caplet
Goody's Extra Strength Headache Powder 33 mg, 1 powder packet

More caffeine

BC Powder 65 mg, 1 powder packet
Excedrin Extra Strength 65 mg, 1 caplet
Excedrin Migraine 65 mg, 1 caplet

FAQ

Is Midol Complete high in caffeine?

It is moderate. One caplet of Midol Complete contains 60 mg, which is 63% of the 95 mg in an 8 fl oz cup of brewed coffee.

Can I take Midol Complete at night?

Earlier is better. Taken at 7 pm, it leaves about 36 mg in an average adult at an 11 pm bedtime. The latest time for an 11 pm bedtime is about 9:25 pm.

How long does the caffeine in Midol Complete last?

It peaks about 70 minutes after you take it. Of the 60 mg, about 27 mg is still in you 6 hours later and 12 mg after 12 hours, for an average adult with a 5-hour half-life.

Does Midol Complete have more caffeine than a cup of coffee?

No. One caplet of Midol Complete contains 60 mg; an 8 fl oz cup of coffee has 95 mg.

Method and limits

The caffeine figure comes from DailyMed (U.S. National Library of Medicine); it is the amount the label lists per unit. The curves use a standard one-compartment model with an average 5-hour half-life and a sleep-friendly line of 50 mg; your own body may clear caffeine faster or slower. How it works has the details.

These are estimates for information, not medical advice. This is a medicine: follow the label and ask your pharmacist or doctor about dosing.